Nowadays, knowledge has essential role in achieving strategic objectives and gain competitive advantage. Knowledge should be managed like any other organizational resource. Therefore, one of the most important considerations in order properly implement the knowledge management process, is the identification and Ranking of the factors affecting the implementation of knowledge management. In this research, to identify organizational factors affecting the proper implementation of knowledge management, review of the literature was performed and then interpretive structural modeling was used for defining the relations between dimensions and Indicators of effective on implementation of Knowledge Management. The results show that the model contains seven elements: organizational culture, technology, organizational structure, strategy, human resources, leadership and benchmarking. Benchmarking and then technology have the highest driving power, and there are also less dependent on ot her factors, so it is necessary for the successful implementation of knowledge management, they should be given the utmost attention. After that, strategy, structure and leadership have higher driving power and dependence. On The fourth level, culture and human resources are, that have the least driving power and highest dependence.